Therapeutic Surgical Management of Palpable Melanoma Groin Metastases: Superficial or Combined Superficial and Deep Groin Lymph Node Dissection
Identifieur interne : 000274 ( France/Analysis ); précédent : 000273; suivant : 000275Therapeutic Surgical Management of Palpable Melanoma Groin Metastases: Superficial or Combined Superficial and Deep Groin Lymph Node Dissection
Auteurs : A. P. T. Van Der Ploeg [Pays-Bas] ; A. C. J. Van Akkooi [Pays-Bas] ; P. I. M. Schmitz [Pays-Bas] ; A. N. Van Geel [Pays-Bas] ; J. H. De Wilt [Pays-Bas] ; A. M. M. Eggermont [Pays-Bas, France] ; C. Verhoef [Pays-Bas]Source :
- Annals of Surgical Oncology [ 1068-9265 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aine (), Aine (anatomopathologie), Femelle, Humains, Jeune adulte, Lymphadénectomie, Mâle, Mélanome (), Mélanome (anatomopathologie), Mélanome (mortalité), Métastase lymphatique, Pronostic, Récidive tumorale locale (), Récidive tumorale locale (anatomopathologie), Récidive tumorale locale (mortalité), Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs cutanées (), Tumeurs cutanées (mortalité), Tumeurs cutanées (secondaire), Études de suivi, Études rétrospectives.
- MESH :
- anatomopathologie : Aine, Mélanome, Récidive tumorale locale.
- mortalité : Mélanome, Récidive tumorale locale, Tumeurs cutanées.
- secondaire : Tumeurs cutanées.
- Adulte, Adulte d'âge moyen, Aine, Femelle, Humains, Jeune adulte, Lymphadénectomie, Mâle, Mélanome, Métastase lymphatique, Pronostic, Récidive tumorale locale, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Tumeurs cutanées, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Groin (pathology), Groin (surgery), Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Melanoma (mortality), Melanoma (pathology), Melanoma (surgery), Middle Aged, Neoplasm Recurrence, Local (mortality), Neoplasm Recurrence, Local (pathology), Neoplasm Recurrence, Local (surgery), Prognosis, Retrospective Studies, Skin Neoplasms (mortality), Skin Neoplasms (secondary), Skin Neoplasms (surgery), Survival Rate, Young Adult.
- MESH :
- mortality : Melanoma, Neoplasm Recurrence, Local, Skin Neoplasms.
- pathology : Groin, Melanoma, Neoplasm Recurrence, Local.
- secondary : Skin Neoplasms.
- surgery : Groin, Melanoma, Neoplasm Recurrence, Local, Skin Neoplasms.
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Prognosis, Retrospective Studies, Survival Rate, Young Adult.
Abstract
Management of patients with clinically detectable lymph node metastasis to the groin is by ilioinguinal or combined superficial and deep groin dissection (CGD) according to most literature, but in practice superficial groin dissection (SGD) only is still performed in some centers. The aim of this study is to evaluate the experience in CGD versus SGD patients in our center.
Between 1991 and 2009, 121 therapeutic CGD and 48 SGD were performed in 169 melanoma patients with palpable groin metastases at our institute. Median follow-up was 20 and, for survivors, 45 months.
In this heterogeneous group of patients, overall (OS) and disease-free survival, local control rates, and morbidity rates were not significantly different between CGD and SGD patients. However, CGD patients had a trend towards more chronic lymphedema. Superficial lymph node ratio, the number of positive superficial lymph nodes, and the presence of deep nodes were prognostic factors for survival. CGD patients with involved deep lymph nodes (24.8%) had estimated 5-year OS of 12% compared with 40% with no involved deep lymph nodes (
This study demonstrated that survival and local control do not differ for patients with palpable groin metastases treated by CGD or SGD. Patients without pathological iliac nodes on CT might safely undergo SGD, while CGD might be reserved for patients with multiple positive nodes on SGD and/or positive deep nodes on CT scan.
Url:
DOI: 10.1245/s10434-011-1741-0
PubMed: 21537867
PubMed Central: 3192282
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000C13
- to stream Pmc, to step Curation: 000C12
- to stream Pmc, to step Checkpoint: 002C67
- to stream PubMed, to step Corpus: 002643
- to stream PubMed, to step Curation: 002643
- to stream PubMed, to step Checkpoint: 002643
- to stream Ncbi, to step Merge: 004321
- to stream Ncbi, to step Curation: 004321
- to stream Ncbi, to step Checkpoint: 004321
- to stream Main, to step Merge: 004A72
- to stream Main, to step Curation: 004A40
- to stream Main, to step Exploration: 004A40
- to stream France, to step Extraction: 000274
Links to Exploration step
PMC:3192282Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Therapeutic Surgical Management of Palpable Melanoma Groin Metastases: Superficial or Combined Superficial and Deep Groin Lymph Node Dissection</title><author><name sortKey="Van Der Ploeg, A P T" sort="Van Der Ploeg, A P T" uniqKey="Van Der Ploeg A" first="A. P. T." last="Van Der Ploeg">A. P. T. Van Der Ploeg</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Akkooi, A C J" sort="Van Akkooi, A C J" uniqKey="Van Akkooi A" first="A. C. J." last="Van Akkooi">A. C. J. Van Akkooi</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schmitz, P I M" sort="Schmitz, P I M" uniqKey="Schmitz P" first="P. I. M." last="Schmitz">P. I. M. Schmitz</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Trials and Statistics, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Trials and Statistics, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Geel, A N" sort="Van Geel, A N" uniqKey="Van Geel A" first="A. N." last="Van Geel">A. N. Van Geel</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Wilt, J H" sort="De Wilt, J H" uniqKey="De Wilt J" first="J. H." last="De Wilt">J. H. De Wilt</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff3">Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Eggermont, A M M" sort="Eggermont, A M M" uniqKey="Eggermont A" first="A. M. M." last="Eggermont">A. M. M. Eggermont</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Verhoef, C" sort="Verhoef, C" uniqKey="Verhoef C" first="C." last="Verhoef">C. Verhoef</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21537867</idno><idno type="pmc">3192282</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192282</idno><idno type="RBID">PMC:3192282</idno><idno type="doi">10.1245/s10434-011-1741-0</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000C13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C13</idno><idno type="wicri:Area/Pmc/Curation">000C12</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C12</idno><idno type="wicri:Area/Pmc/Checkpoint">002C67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002C67</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002643</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002643</idno><idno type="wicri:Area/PubMed/Curation">002643</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002643</idno><idno type="wicri:Area/PubMed/Checkpoint">002643</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002643</idno><idno type="wicri:Area/Ncbi/Merge">004321</idno><idno type="wicri:Area/Ncbi/Curation">004321</idno><idno type="wicri:Area/Ncbi/Checkpoint">004321</idno><idno type="wicri:doubleKey">1068-9265:2011:Van Der Ploeg A:therapeutic:surgical:management</idno><idno type="wicri:Area/Main/Merge">004A72</idno><idno type="wicri:Area/Main/Curation">004A40</idno><idno type="wicri:Area/Main/Exploration">004A40</idno><idno type="wicri:Area/France/Extraction">000274</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Therapeutic Surgical Management of Palpable Melanoma Groin Metastases: Superficial or Combined Superficial and Deep Groin Lymph Node Dissection</title><author><name sortKey="Van Der Ploeg, A P T" sort="Van Der Ploeg, A P T" uniqKey="Van Der Ploeg A" first="A. P. T." last="Van Der Ploeg">A. P. T. Van Der Ploeg</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Akkooi, A C J" sort="Van Akkooi, A C J" uniqKey="Van Akkooi A" first="A. C. J." last="Van Akkooi">A. C. J. Van Akkooi</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schmitz, P I M" sort="Schmitz, P I M" uniqKey="Schmitz P" first="P. I. M." last="Schmitz">P. I. M. Schmitz</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Trials and Statistics, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Trials and Statistics, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Geel, A N" sort="Van Geel, A N" uniqKey="Van Geel A" first="A. N." last="Van Geel">A. N. Van Geel</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Wilt, J H" sort="De Wilt, J H" uniqKey="De Wilt J" first="J. H." last="De Wilt">J. H. De Wilt</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff3">Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Eggermont, A M M" sort="Eggermont, A M M" uniqKey="Eggermont A" first="A. M. M." last="Eggermont">A. M. M. Eggermont</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff4">Institut de Cancérologie Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cancérologie Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Verhoef, C" sort="Verhoef, C" uniqKey="Verhoef C" first="C." last="Verhoef">C. Verhoef</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgical Oncology, Erasmus University Medical Center – Daniel den Hoed Cancer Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Annals of Surgical Oncology</title><idno type="ISSN">1068-9265</idno><idno type="eISSN">1534-4681</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Groin (pathology)</term><term>Groin (surgery)</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Male</term><term>Melanoma (mortality)</term><term>Melanoma (pathology)</term><term>Melanoma (surgery)</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local (mortality)</term><term>Neoplasm Recurrence, Local (pathology)</term><term>Neoplasm Recurrence, Local (surgery)</term><term>Prognosis</term><term>Retrospective Studies</term><term>Skin Neoplasms (mortality)</term><term>Skin Neoplasms (secondary)</term><term>Skin Neoplasms (surgery)</term><term>Survival Rate</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aine ()</term><term>Aine (anatomopathologie)</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lymphadénectomie</term><term>Mâle</term><term>Mélanome ()</term><term>Mélanome (anatomopathologie)</term><term>Mélanome (mortalité)</term><term>Métastase lymphatique</term><term>Pronostic</term><term>Récidive tumorale locale ()</term><term>Récidive tumorale locale (anatomopathologie)</term><term>Récidive tumorale locale (mortalité)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Tumeurs cutanées ()</term><term>Tumeurs cutanées (mortalité)</term><term>Tumeurs cutanées (secondaire)</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Aine</term><term>Mélanome</term><term>Récidive tumorale locale</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Melanoma</term><term>Neoplasm Recurrence, Local</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Mélanome</term><term>Récidive tumorale locale</term><term>Tumeurs cutanées</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Groin</term><term>Melanoma</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs cutanées</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Groin</term><term>Melanoma</term><term>Neoplasm Recurrence, Local</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lymph Node Excision</term><term>Lymphatic Metastasis</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Retrospective Studies</term><term>Survival Rate</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aine</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lymphadénectomie</term><term>Mâle</term><term>Mélanome</term><term>Métastase lymphatique</term><term>Pronostic</term><term>Récidive tumorale locale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Tumeurs cutanées</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Management of patients with clinically detectable lymph node metastasis to the groin is by ilioinguinal or combined superficial and deep groin dissection (CGD) according to most literature, but in practice superficial groin dissection (SGD) only is still performed in some centers. The aim of this study is to evaluate the experience in CGD versus SGD patients in our center.</p></sec><sec><title>Methods</title><p>Between 1991 and 2009, 121 therapeutic CGD and 48 SGD were performed in 169 melanoma patients with palpable groin metastases at our institute. Median follow-up was 20 and, for survivors, 45 months.</p></sec><sec><title>Results</title><p>In this heterogeneous group of patients, overall (OS) and disease-free survival, local control rates, and morbidity rates were not significantly different between CGD and SGD patients. However, CGD patients had a trend towards more chronic lymphedema. Superficial lymph node ratio, the number of positive superficial lymph nodes, and the presence of deep nodes were prognostic factors for survival. CGD patients with involved deep lymph nodes (24.8%) had estimated 5-year OS of 12% compared with 40% with no involved deep lymph nodes (<italic>p</italic> = 0.001). Preoperative computed tomography (CT) scan had high negative predictive value of 91% for detection of pelvic nodal involvement.</p></sec><sec><title>Conclusions</title><p>This study demonstrated that survival and local control do not differ for patients with palpable groin metastases treated by CGD or SGD. Patients without pathological iliac nodes on CT might safely undergo SGD, while CGD might be reserved for patients with multiple positive nodes on SGD and/or positive deep nodes on CT scan.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name></author><author><name sortKey="Ross, Mi" uniqKey="Ross M">MI Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karakousis, Cp" uniqKey="Karakousis C">CP Karakousis</name></author><author><name sortKey="Driscoll, Dl" uniqKey="Driscoll D">DL Driscoll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karakousis, Cp" uniqKey="Karakousis C">CP Karakousis</name></author><author><name sortKey="Emrich, Lj" uniqKey="Emrich L">LJ Emrich</name></author><author><name sortKey="Rao, U" uniqKey="Rao U">U Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allan, Cp" uniqKey="Allan C">CP Allan</name></author><author><name sortKey="Hayes, Aj" uniqKey="Hayes A">AJ Hayes</name></author><author><name sortKey="Thomas, Jm" uniqKey="Thomas J">JM Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mack, La" uniqKey="Mack L">LA Mack</name></author><author><name sortKey="Mckinnon, Jg" uniqKey="Mckinnon J">JG McKinnon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sterne, Gd" uniqKey="Sterne G">GD Sterne</name></author><author><name sortKey="Murray, Ds" uniqKey="Murray D">DS Murray</name></author><author><name sortKey="Grimley, Rp" uniqKey="Grimley R">RP Grimley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strobbe, Lj" uniqKey="Strobbe L">LJ Strobbe</name></author><author><name sortKey="Jonk, A" uniqKey="Jonk A">A Jonk</name></author><author><name sortKey="Hart, Aa" uniqKey="Hart A">AA Hart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mann, Gb" uniqKey="Mann G">GB Mann</name></author><author><name sortKey="Coit, Dg" uniqKey="Coit D">DG Coit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccarthy, Jg" uniqKey="Mccarthy J">JG McCarthy</name></author><author><name sortKey="Haagensen, Cd" uniqKey="Haagensen C">CD Haagensen</name></author><author><name sortKey="Herter, Fp" uniqKey="Herter F">FP Herter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coit, Dg" uniqKey="Coit D">DG Coit</name></author><author><name sortKey="Brennan, Mf" uniqKey="Brennan M">MF Brennan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Tm" uniqKey="Hughes T">TM Hughes</name></author><author><name sortKey="A Ern, Rp" uniqKey="A Ern R">RP A’Hern</name></author><author><name sortKey="Thomas, Jm" uniqKey="Thomas J">JM Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Tm" uniqKey="Hughes T">TM Hughes</name></author><author><name sortKey="Thomas, Jm" uniqKey="Thomas J">JM Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, T" uniqKey="Meyer T">T Meyer</name></author><author><name sortKey="Merkel, S" uniqKey="Merkel S">S Merkel</name></author><author><name sortKey="Gohl, J" uniqKey="Gohl J">J Gohl</name></author><author><name sortKey="Hohenberger, W" uniqKey="Hohenberger W">W Hohenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finck, Sj" uniqKey="Finck S">SJ Finck</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Mann, Bd" uniqKey="Mann B">BD Mann</name></author><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karakousis, Cp" uniqKey="Karakousis C">CP Karakousis</name></author><author><name sortKey="Driscoll, Dl" uniqKey="Driscoll D">DL Driscoll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kretschmer, L" uniqKey="Kretschmer L">L Kretschmer</name></author><author><name sortKey="Neumann, C" uniqKey="Neumann C">C Neumann</name></author><author><name sortKey="Preusser, Kp" uniqKey="Preusser K">KP Preusser</name></author><author><name sortKey="Marsch, Wc" uniqKey="Marsch W">WC Marsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y Xing</name></author><author><name sortKey="Badgwell, Bd" uniqKey="Badgwell B">BD Badgwell</name></author><author><name sortKey="Ross, Mi" uniqKey="Ross M">MI Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spillane, Aj" uniqKey="Spillane A">AJ Spillane</name></author><author><name sortKey="Cheung, Bl" uniqKey="Cheung B">BL Cheung</name></author><author><name sortKey="Winstanley, J" uniqKey="Winstanley J">J Winstanley</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spillane, Aj" uniqKey="Spillane A">AJ Spillane</name></author><author><name sortKey="Winstanley, J" uniqKey="Winstanley J">J Winstanley</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spillane, Aj" uniqKey="Spillane A">AJ Spillane</name></author><author><name sortKey="Saw, Rp" uniqKey="Saw R">RP Saw</name></author><author><name sortKey="Tucker, M" uniqKey="Tucker M">M Tucker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tobin, Mb" uniqKey="Tobin M">MB Tobin</name></author><author><name sortKey="Lacey, Hj" uniqKey="Lacey H">HJ Lacey</name></author><author><name sortKey="Meyer, L" uniqKey="Meyer L">L Meyer</name></author><author><name sortKey="Mortimer, Ps" uniqKey="Mortimer P">PS Mortimer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faries, Mb" uniqKey="Faries M">MB Faries</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author><author><name sortKey="Cochran, A" uniqKey="Cochran A">A Cochran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spillane, Aj" uniqKey="Spillane A">AJ Spillane</name></author><author><name sortKey="Tucker, M" uniqKey="Tucker M">M Tucker</name></author><author><name sortKey="Pasquali, S" uniqKey="Pasquali S">S Pasquali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singletary, Se" uniqKey="Singletary S">SE Singletary</name></author><author><name sortKey="Shallenberger, R" uniqKey="Shallenberger R">R Shallenberger</name></author><author><name sortKey="Guinee, Vf" uniqKey="Guinee V">VF Guinee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name></author><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name></author><author><name sortKey="Soong, Sj" uniqKey="Soong S">SJ Soong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balch, Cm" uniqKey="Balch C">CM Balch</name></author><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name></author><author><name sortKey="Soong, Sj" uniqKey="Soong S">SJ Soong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonk, A" uniqKey="Jonk A">A Jonk</name></author><author><name sortKey="Kroon, Bb" uniqKey="Kroon B">BB Kroon</name></author><author><name sortKey="Rumke, P" uniqKey="Rumke P">P Rumke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karakousis, Cp" uniqKey="Karakousis C">CP Karakousis</name></author><author><name sortKey="Driscoll, Dl" uniqKey="Driscoll D">DL Driscoll</name></author><author><name sortKey="Rose, B" uniqKey="Rose B">B Rose</name></author><author><name sortKey="Walsh, Dl" uniqKey="Walsh D">DL Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Badgwell, B" uniqKey="Badgwell B">B Badgwell</name></author><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y Xing</name></author><author><name sortKey="Gershenwald, Je" uniqKey="Gershenwald J">JE Gershenwald</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Pays-Bas</li></country><region><li>Gueldre</li><li>Hollande-Méridionale</li></region><settlement><li>Nimègue</li><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Der Ploeg, A P T" sort="Van Der Ploeg, A P T" uniqKey="Van Der Ploeg A" first="A. P. T." last="Van Der Ploeg">A. P. T. Van Der Ploeg</name></region><name sortKey="De Wilt, J H" sort="De Wilt, J H" uniqKey="De Wilt J" first="J. H." last="De Wilt">J. H. De Wilt</name><name sortKey="De Wilt, J H" sort="De Wilt, J H" uniqKey="De Wilt J" first="J. H." last="De Wilt">J. H. De Wilt</name><name sortKey="Eggermont, A M M" sort="Eggermont, A M M" uniqKey="Eggermont A" first="A. M. M." last="Eggermont">A. M. M. Eggermont</name><name sortKey="Schmitz, P I M" sort="Schmitz, P I M" uniqKey="Schmitz P" first="P. I. M." last="Schmitz">P. I. M. Schmitz</name><name sortKey="Van Akkooi, A C J" sort="Van Akkooi, A C J" uniqKey="Van Akkooi A" first="A. C. J." last="Van Akkooi">A. C. J. Van Akkooi</name><name sortKey="Van Geel, A N" sort="Van Geel, A N" uniqKey="Van Geel A" first="A. N." last="Van Geel">A. N. Van Geel</name><name sortKey="Verhoef, C" sort="Verhoef, C" uniqKey="Verhoef C" first="C." last="Verhoef">C. Verhoef</name></country><country name="France"><noRegion><name sortKey="Eggermont, A M M" sort="Eggermont, A M M" uniqKey="Eggermont A" first="A. M. M." last="Eggermont">A. M. M. Eggermont</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000274 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000274 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= PMC:3192282
|texte= Therapeutic Surgical Management of Palpable Melanoma Groin Metastases: Superficial or Combined Superficial and Deep Groin Lymph Node Dissection
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:21537867" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |